36 下列何種抗癲癇藥物可阻斷 NMDA 受體？
(A) Ethosuximide
(B) Vigabatrin
(C) Lamotrigine
(D) Felbamate

可阻斷 NMDA 受體：

抗癲癇特殊機轉抑制NMDA：Felbam...

Ethosuximide：抑制視丘神經元的鈣管道，抑制運動皮質的神經傳送、降低大腦皮質的興奮。

Lamotrigine：作用於電位敏感的鈉通道，安定神經膜及抑制興奮性氨基酸 (Glutamate)的釋放。

vigabatrin : GABA tr...

Ethosuximide：抑制T typ...

（A）Ethosuximide（抑制T型Ca²⁺通道）：Absence seizure失神性癲癇（首選）【→貧血、血小板低下】

（B）Vigabatrin（GABA-transaminase不可逆抑制劑，增強GABA作用）：West's syndrome（S-form）、Partial seizure【→體重↑、視野障礙】

（C）Lamotrigine（阻斷Na⁺通道）：孕婦可用之Anticonvulsant；Lennox-Gestaut症候群（低於16歲）【→Dose-related紅疹；SJS】

（D）Felbamate（阻斷Na⁺通道、Ca²⁺通道、NMDA-R）：廣效性【→體重↓、再生性不良性貧血；毒性代謝物：2-Phenylpropenal】

Carbamate anticonvulsant agents are newer antiepileptic drugs whose exact mechanism of action is uncertain. It has some inhibitory effect at the N-methyl-D-aspartate (NMDA) receptors and slightly potentiates gamma-aminobutyric acid (GABA) activity. It has a broad spectrum of activity but is only used in patients who are unresponsive to other anticonvulsant drugs, as it can cause severe reactions such as aplastic anemia, hepatitis and liver failure.

Felbamate：抑制NMDA 受體、...