41. A highly active muscle cell is subjected to extreme mechanical work, causing a sharp, sustained acceleration in the rate of ATP hydrolysis. The initial free energy released by this process is used primarily for mechanical work, such as muscle contraction. Considering the subsequent shift in the concentrations of ATP, ADP, and inorganic phosphate (Pi) within the cell, which statement best describes the immediate, self-regulating response mediated by allosteric control mechanisms?
(A) The accumulation of inorganic phosphate (Pi) acts as a competitive inhibitor, competing with substrate molecules for the active sites of catabolíc enzymes, thus slowing down ATP synthesis.
(B) The reduction in ATP concentration stabilizes the inactive form of key catabolic enzymes, causing the overall pace of catabolism to decrease.
(C) The remaining ATP binds to its specific regulatory sites on anabolic enzymes, inhibiting them, while simultaneously promoting the activity of catabolic enzymes.
(D) The rising concentration of ADP functions as an allosteric activator, stabilizing the active conformations of key catabolic enzymes and thereby accelerating the overall rate of ATP regeneration.
(E) The decrease in ATP concentration forces the cell's metabolic pathways closer to equilibrium, which increases the amount of work the cell can perform, according to the Free Energy principle (AG).