申論題

3. Colorectal cancer (CRC) is the third most common cancer worldwide. The performance of guaiac and immunochemical fecal occult blood tests (abbreviated as G-FOBT and FIT, respectively) for the detection of CRC was compared anong 257 asymptomatic and 20 confirmed cancer patients. The results of colonoscopy for all of the 277 subjects were postulated as the gold standard. (Modified from the article: Clin Exp Gastroenterol. 2015； 8: 279-284.)

(A) Recreate a 2 x 2 table of G-FOBT (positive & negative) vs. FIT (positive & ncgative) using the following table. Set up the hypotheses to determnine whether there is a statistically significant association between the two tests. What statistical test is appropriate to test the hypotheses? (12 marks)