37. Which of the following statements about sickle cell anemia is incorrect? (A) The red blood cells have a crescent shape making them difficult to pass through the capillaries. (B) Hb S (sickle hemoglobin) differs from normal Hb A by only one amino acid substitution. (C) The difference between the molecular structures of Hb S and normal Hb A is the presence of a hydrophobic protrusion on the surface of Hb S protein. (D) The solubility of dcoxyHb S is lower than that of deoxyHb A, so insoluble Hb S fibers may be observed frequently. (E) When binding with oxygen, Hb S can interact with the cell membrane and cause cell damage.