4. (續前題)上述患者住院之後的檢查結果如下:ANA 1:1280 nucleolar pattern,IgG 2042 mg/dL,IgA 365 mg/dL,IgM 156 mg/dL;PFT:moderate restrictive ventilatory defect with 56% of predicted DLCO;esophageal motility test 顯示食道下部 2/3 有不正常蠕動。試問下列何種藥物對此患者最有幫助?
(A) Salazopyrine
(B) D-penicillamine
(C) Methotrexate
(D) IVIG
(E) Calcium channel blocker